The Impact of Orgasms on Brain Chemistry

Written by Alissa Merrill

Flower & Tonic stems from my unique experience as a sales consultant in the pharmaceutical, cosmeceutical, nutraceutical and healthcare software industries. As a "Big Pharma" rep for Bristol Myers Squibb & Novartis, I was integral in the launch of several blockbuster drugs. My therapeutic areas of expertise included the treatment of diabetes, cardiovascular, sexual health, ADHD, anxiety depression, and movement disorders.

Tanya Griffin of on the impact that orgasms have on Cortisol, Dopamine & Seratonin


Exploring the Physiological Effects of Orgasms

On last Friday’s episode, Alissa asked Tanya Griffin of about the impact that orgasms have on 3 major hormones.

Click play on the YouTube Video below to hear Tanya’s response & Check out and take the sex quiz designed to help you connect with your partner!

The Impact of Orgasms on Brain Chemistry

Orgasms are not only enjoyable, but they can have a profound effect on brain chemistry. During orgasm, hormones such as cortisol, dopamine, and serotonin play a critical role in regulating the body’s response to sexual pleasure. Let’s take a look at how each of these hormones interact with orgasm and how they affect our overall well-being.


Cortisol is a hormone released by the adrenal glands during stress or arousal. It plays an important role in regulating the body’s fight-or-flight response and can also influence sexual arousal. During orgasm, cortisol levels increase sharply, helping to maintain arousal and providing a sense of relaxation afterwards. This is why many people find that orgasms help them relax after a stressful day.


Dopamine is another hormone released during arousal, and it plays an important role in regulating pleasure and reward pathways in the brain. During orgasm, dopamine levels spike dramatically, leading to feelings of euphoria and intense pleasure. This burst of dopamine is also thought to be responsible for the “afterglow” feeling that many people experience after having an orgasm.


Serotonin is another hormone involved in sexual pleasure, but its effects are more subtle than those of cortisol or dopamine. While serotonin does not directly contribute to arousal or pleasure during sex, it does play an important role in regulating mood and emotions afterward. Studies have found that increased serotonin levels following an orgasm can lead to improved moods and reduced stress levels for up to 24 hours after sex has taken place.

In summary, orgasms can have powerful effects on our brain chemistry due to the release of hormones such as cortisol, dopamine, and serotonin during sexual activity. These hormones help regulate our fight-or-flight responses as well as our feelings of pleasure and reward during sex. They also contribute to feelings of relaxation afterwards as well as improved moods for up to 24 hours after sex has taken place. Knowing this information can help us better understand how orgasms affect us emotionally and physically so we can make informed decisions about our health going forward!

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