CBD interacts with the Cytochrome P450 enzyme system in the liver and could potentially prevent other drugs from accessing these enzymes, causing some of them to build up in the bloodstream affecting potency. It is unknown how long any given dose of CBD would exert an effect.
This enzyme system is involved in processing about 60% of all pharmaceuticals on the market, including common psych drugs like Klonopin, Valium, Xanax, and a long list of antihistamines, antiretrovirals, and steroids, to name a few.
Anyone taking significant doses of CBD and other drugs simultaneously should be cautious. People on chemotherapy drugs and warfarin blood thinners should be on alert given how easily an increased blood concentration of either could lead to serious negative side effects.
If you have blood pressure issues, are taking prescription drugs or have ever been warned about ingesting fruit juice, citrus or fermented products, consult your doctor before using CBD oil.
A report from the American Academy of Pediatrics (AAP) published in the journal Pediatrics cautions pregnant women and nursing mothers to avoid cannabis use due to possible adverse developmental effects on their baby.
In a study reviewed for the report, short-term exposure to CBD was found to increase the permeability of the placental barrier, potentially placing the fetus at risk from certain substances.
Studies are needed and hundreds are underway.
Knowledge on cannabinoid medicine is in the very early stages and it’s best to proceed with caution.
Safety is knowing exactly what is in the CBD product you are using.
According to a report by the World Health Organization CBD exhibits no effects indicative of any abuse or dependence potential.
There is no evidence at the moment that CBD oil tends to be either physically or psychologically habit-forming.
Small-scale studies have looked into the safety of CBD in adults and concluded that adults tend to tolerate a wide range of doses well. Researchers have found no significant side effects on the central nervous system, vital signs, or mood, even among people who used high dosages.
Some patients reported diarrhea and changes in appetite or weight. The most common side effect was tiredness..
CBD DOSING AND SAFETY | WHICH METHOD IS BEST?
Everyone metabolizes food, alcohol, supplements, and medicine differently. When someone asks how to dose CBD, as important as it is to offer specific directions and guidelines, it is difficult to provide an easy answer.
How a person responds to medicine (plant-based or pharmaceutical) is influenced by genetic makeup, biological sex, lifestyle, mood, how they slept, what they ate that day, and of course, overall health.
These factors combined with the quality and type of product, formulation and delivery system, determine how well CBD may work.
How will CBD make you feel? Think acetaminophen (Tylenol) and ibuprofen… they should relieve pain but you would not expect to “feel” anything in terms of a high or euphoria effect. Will it make you feel better? Again using acetaminophen as an example, 250 mg might be enough to relieve a headache, but you may need 500 mg to treat a bad headache or fever.
For these products, you can dose in liquid suspension, chewable tablets, suppositories and all in varying strengths. CBD dosing can seem complicated and overwhelming but does not have to be.
We will dig in way deeper with guidance directly from doctors, scientists, pharmacists, and caregivers.
The typical starting dose for CBD is 10 mg once or twice daily and with any medication. It is always best to start low and go slow.
Taking CBD on a full stomach allows more CBD to reach the circulatory system and faster. Some suggest taking CBD with Omega-3 ensures maximum potential benefit.
On average the effects of CBD oil last 3-5 hours.
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